Author:
Kolkenbeck-Ruh Andrea,Soepnel Larske M.,Crouch Simone H.,Naidoo Sanushka,Smith Wayne,Norris Shane A.,Davies Justine,Ware Lisa J.
Abstract
AbstractBackgroundLeft ventricular hypertrophy (LVH) is a known marker of increased risk in developing future life-threating CVD, though it is unclear how health risk factors, such as obesity, blood pressure and tobacco use, associate with left ventricular (LV) remodelling and LVH across generations of urban African populations.MethodsBlack female adults (n=123; age: 29-68 years) and their children (n=64; age: 4-10; 55% female) were recruited from the Birth to Twenty Plus Cohort in Soweto, South Africa. Tobacco and alcohol use, physical activity, presence of diabetes mellitus, heart disease and medication were self-reported. Height, weight, and blood pressure were measured in triplicate. Echocardiography was used to assess LV mass at end-diastole, perpendicular to the long axis of the LV and indexed to body surface area to determine LVH.ResultsHypertension and obesity prevalence were 35.8% and 59.3% for adults and 45.3% and 6.3% for children. Self-reported tobacco use in adults was 22.8%. LVH prevalence was 35.8% (n=44) in adults (75% eccentric; 25% concentric), and 6.3% (n=4) in children (all eccentric). Prevalence of concentric remodelling was 15.4% (n=19) in adults and observed in one child. In adults, obesity (OR: 2.54 (1.07-6.02; p=0.02) and hypertension (3.39 (1.08-10.62; p=0.04) significantly increased the odds of LVH, specifically eccentric LVH, while concentric LVH was associated with self-reported tobacco use (OR: 4.58 (1.18-17.73; p=0.03; n=11). Although no logistic regression was run within children, of the four children LVH, three had elevated blood pressure and the child with normal blood pressure was overweight.ConclusionsThe association between obesity, hypertension, tobacco use and LVH in adults, and the 6% prevalence of LVH in children, calls for stronger public health efforts to control risk factors and monitor children at who are risk.
Publisher
Cold Spring Harbor Laboratory
Reference67 articles.
1. Epidemiology and aetiology of heart failure
2. Bradshaw D , Groenewald P , Laubscher R , Nannan N , Nojilana B , Norman R , et al. Initial burden of disease estimates for South Africa, 2000=:J: original article. Samj. 2003.
3. Bhatia RS , Tu J V. , Lee DS , Austin PC , Fang J , Haouzi A , et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med. 2006.
4. Mozaffarian D , Benjamin EJ , Go AS , Arnett DK , Blaha MJ , Cushman M , et al. Heart disease and stroke statistics-2015 update=:J: A report from the American Heart Association. Circulation. 2015.
5. Lee DS , Gona P , Vasan RS , Larson MG , Benjamin EJ , Wang TJ , et al. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: Insights from the framingham heart study of the national heart, lung, and blood institute. Circulation. 2009.