Author:
Vuckovich Joseph A.,Semel Mara E.,Baxter Mark G.
Abstract
A recent studysuggests that lesions to all major areas of the cholinergic
basal forebrain in the rat (medial septum, horizontal limb of the diagonal
band of Broca, and nucleus basalis magnocellularis) impair a spatial working
memory task. However, this experiment used a surgical technique that mayhave
damaged cerebellar Purkinje cells. The present studytested rats with
highlyselective lesions of cholinergic neurons in all major areas of the basal
forebrain on a spatial working memorytask in the radial arm maze. In
postoperative testing, there were no significant differences between lesion
and control groups in working memory, even with a delayperiod of 8 h, with the
exception of a transient impairment during the first 2 d of postoperative
testing at shorter delays (0 or 2 h). This finding corroborates other results
that indicate that the cholinergic basal forebrain does not playa significant
role in spatial working memory. Furthermore, it underscores the presence of
intact memoryfunctions after cholinergic basal forebrain damage, despite
attentional impairments that follow these lesions, demonstrated in other task
paradigms.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
36 articles.
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