Author:
Battaglia Francesco P.,Sutherland Gary R.,McNaughton Bruce L.
Abstract
The sleeping neocortex shows nested oscillatory activity in different
frequency ranges, characterized by fluctuations between
“up-states” and “down-states.” High-density neuronal
ensemble recordings in rats now reveal the interaction between synchronized
activity in the hippocampus and neocortex: Electroencephalographic sharp waves
in the hippocampus were more probable during down-states than during
up-states, and tended to coincide with transitions from down-states to
up-states. The form of cortical activity fluctuations and their interactions
with sharp waves depend on sleep depth: In deeper sleep stages, characterized
by strong neocortical oscillation in the delta range or slower (∼0.8-4
Hz), sharp-wave-triggered peri-event time histograms (PETH) are consistent
with a longer duration for down-states than for up-states. In lighter sleep,
the sharp-wave-triggered PETH suggested longer up-states than down-states.
These results highlight the interplay in the hippocampal/neocortical loop:
Decreased neocortical input during down-states may be a factor in generation
of sharp waves. In turn, sharp waves may facilitate down-to-up transitions.
This interplay may reflect joint memory trace reactivation in the hippocampus
and in the neocortex, possibly contributing to consolidation of long-term
memory: Off-line reactivation of recent neural activity patterns in the
hippocampus occurs during 50-100-msec electroencephalographic sharp waves,
corresponding to pyramidal-cell population bursts. The neocortical up-states
starting in correspondence with sharp waves may be influenced by the
reactivated information carried by the hippocampal sharp wave.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
266 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献