Author:
Ergorul Ceren,Eichenbaum Howard
Abstract
Previous studies have indicated that nonhuman animals might have a capacity
for episodic-like recall reflected in memory for “what” events
that happened “where” and “when”. These studies did
not identify the brain structures that are critical to this capacity. Here we
trained rats to remember single training episodes, each composed of a series
of odors presented in different places on an open field. Additional
assessments examined the individual contributions of odor and spatial cues to
judgments about the order of events. The results indicated that normal rats
used a combination of spatial (“where”) and olfactory
(“what”) cues to distinguish “when” events occurred.
Rats with lesions of the hippocampus failed in using combinations of spatial
and olfactory cues, even as evidence from probe tests and initial sampling
behavior indicated spared capacities for perception of spatial and odor cues,
as well as some form of memory for those individual cues. These findings
indicate that rats integrate “what,” “where,” and
“when” information in memory for single experiences, and that the
hippocampus is critical to this capacity.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
217 articles.
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