Abstract
AbstractA group of six clinical isolates previously identified asCorynebacterium diphtheriaebiovar Belfanti, isolated from human cutaneous or peritoneum infections and from one dog, were characterized by genomic sequencing, biochemical analysis and mass spectrometry (MALDI-TOF MS). The six isolates were negative for the diphtheria toxin gene. Phylogenetic analyses showed that the six isolates (including FRC0190T) are clearly demarcated fromC. diphtheriae, C. belfantii, C. ulceransandC. pseudotuberculosis. The average nucleotide identity of FRC0190TwithC. diphtheriaeNCTC 11397Twas 92.6%, and was 91.8% withC. belfantiiFRC0043T.C. diphtheriaesubsp.lausannensestrain CHUV2995Tappeared to be a later heterotypic synonym ofC. belfantii(ANI, 99.3%). Phenotyping data revealed an atypical negative or heterogeneous intermediate maltose fermentation reaction for the six isolates. MALDI-TOF MS differentiated the new group from the otherCorynebacteriumtaxa by the presence of specific spectral peaks.rpoBsequences showed identity to atypical, maltose-negativeC. diphtheriaebiovar Belfanti isolates previously described from two cats in the USA. We propose the nameCorynebacterium rouxiisp. nov. for the novel group, with FRC0190T(= CIP 111752T= DSM 110354T) as type strain.
Publisher
Cold Spring Harbor Laboratory
Cited by
2 articles.
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