Author:
De Leonibus Elvira,Oliverio Alberto,Mele Andrea
Abstract
There is now accumulating evidence that the striatal complex in its two
major components, the dorsal striatum and the nucleus accumbens, contributes
to spatial memory. However, the possibility that different striatal subregions
might modulate specific aspects of spatial navigation has not been completely
elucidated. Therefore, in this study, two different learning procedures were
used to determine whether the two striatal components could be distinguished
on the basis of their involvement in spatial learning using different frames
of reference: allocentric and egocentric. The task used involved the detection
of a spatial change in the configuration of four objects placed in an arena,
after the mice had had the opportunity to experience the objects in a constant
position for three previous sessions. In the first part of the study we
investigated whether changes in the place where the animals were introduced
into the arena during habituation and testing could induce a preferential use
of an egocentric or an allocentric frame of reference. In the second part of
the study we performed focal injections of the
N-methyl-d-aspartate (NMDA) receptors' antagonist, AP-5,
within the two subregions immediately after training. The results indicate
that using the two behavioral procedures, the animals rely on an egocentric
and an allocentric spatial frame of reference. Furthermore, they demonstrate
that AP-5 (37.5, 75, and 150 ng/side) injections into the dorsal striatum
selectively impaired consolidation of spatial information in the egocentric
but not in the allocentric procedure. Intra-accumbens AP-5 administration,
instead, impaired animals trained using both procedures.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
50 articles.
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