Author:
Sinturel Flore,Gos Pascal,Petrenko Volodymyr,Hagedorn Claudia,Kreppel Florian,Storch Kai-Florian,Knutti Darko,Liani Andre,Weitz Charles,Emmenegger Yann,Franken Paul,Bonacina Luigi,Dibner Charna,Schibler Ueli
Abstract
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording in freely moving mice, we show that the SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, circadian oscillations persist in the livers of mice devoid of an SCN or oscillators in cells other than hepatocytes. Hence, similar to SCN neurons, hepatocytes can maintain phase coherence in the absence of Zeitgeber signals produced by other organs or environmental cycles.
Funder
Swiss National Science Foundation
European Research Council
State of Geneva
Louis Jeantet Foundation of Medicine
SGED/SSED Young Investigator grant. Work in the laboratory of C.D. was supported by SNSF
SNSF
Vontobel Foundation, the Novartis Consumer Health Foundation
Novartis Consumer Health Foundation, the Swiss Life Foundation
Swiss Life Foundation, the EFSD/Novo
EFSD/Novo Nordisk Program for Diabetes Research in Europe
Olga Mayenfisch Foundation
National Institutes of Health
State of Vaud
Center of Biomedical Research and Education
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
53 articles.
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