Software Application Profile: mrrobust - a tool for performing two-sample summary Mendelian randomization analyses

Abstract

AbstractMotivationIn recent years Mendelian randomization analysis using summary data from genome-wide association studies has become a popular approach for investigating causal relationships in epidemiology. The mrrobust Stata package implements several of the recently developed methods.Implementationmrrobust is freely available as a Stata package.General FeaturesThe package includes inverse variance weighted estimation, as well as a range of median and MR-Egger estimation methods. Using mrrobust, plots can be constructed visualising each estimate either individually or simultaneously. The package also provides statistics such as which are useful in assessing attenuation bias in causal estimates.AvailabilityThe software is freely available from GitHub [https://raw.github.com/remlapmot/mrrobust/master/].