Author:
Genç Erhan,Schlüter Caroline,Fraenz Christoph,Arning Larissa,Metzen Dorothea,Nguyen Huu Phuc,Voelkle Manuel C.,Streit Fabian,Güntürkün Onur,Kumsta Robert,Ocklenburg Sebastian
Abstract
AbstractIntelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the molecular determinants of individual differences in cognitive ability. We therefore studied the association between PGS of intelligence (IQ-PGS), cognitive performance (CP-PGS) and educational attainment (EA-PGS) with a wide range of intelligence facets in a sample of 557 healthy adults. IQ-PGS, CP-PGS and EA-PGS had the highest incremental R2s for general (2.71%; 4.27%; 2.06%), verbal (3.30%; 4.64%; 1.61%) and numerical intelligence (3.06%; 3.24%; 1.26%) and the weakest for non-verbal intelligence (0.89%; 1.47%; 0.70%) and memory (0.80%; 1.06%; 0.67%). These results indicate that PGS derived from light-phenotyping GWAS do not reflect different facets of intelligence equally well, and thus should not be interpreted as genetic indicators of intelligence per se. The findings refine our understanding of how PGS are related to other traits or life outcomes.
Publisher
Cold Spring Harbor Laboratory
Reference51 articles.
1. Intelligence: Knowns and unknowns.
2. Flanagan DP , Dixon SG (2013) The Cattell-Horn-Carroll Theory of Cognitive Abilities. Encyclopedia of Special Education: A Reference for the Education of Children, Adolescents, and Adults with Disabilities and Other Exceptional Individuals
3. Hossiep R , Hasella M , Turck D (2001) BOMAT-advanced-short version: Bochumer Matrizentest. Hogrefe, Göttingen, Germany
4. Raven JC (1990) Court, J.H. , & Raven, J. (1990). Coloured progressive matrices. Manual for Raven’s Progressive Matrices and Vocabulary Scales
5. Hossiep R , Schulte M (2008) BOWIT: Bochumer Wissenstest. Hogrefe,
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献