Author:
Staines Henry M,Kirwan Daniela E,Clark David J,Adams Emily R,Augustin Yolanda,Byrne Rachel L,Cocozza Michael,Cubas-Atienzar Ana I,Cuevas Luis E.,Cusinato Martina,Davies Benedict M O,Davis Mark,Davis Paul,Duvoix Annelyse,Eckersley Nicholas M,Forton Daniel,Fraser Alice J,Garrod Gala,Hadcocks Linda,Hu Qinxue,Johnson Michael,Kay Grant A,Klekotko Kesja,Lewis Zawditu,Macallan Derek C,Mensah-Kane Josephine,Menzies Stefanie,Monahan Irene,Moore Catherine M,Nebe-von-Caron Gerhard,Owen Sophie I,Sainter Chris,Sall Amadou A,Schouten James,Williams Chris,Wilkins John,Woolston Kevin,Fitchett Joseph R A,Krishna Sanjeev,Planche Tim
Abstract
AbstractWe report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than seroconverters who have increased co-morbidity and higher inflammatory markers such as C-Reactive Protein. Higher antibody responses are associated with non-white ethnicity. Antibody responses do not decline during follow up almost to 2 months. Serological assays increase understanding of disease severity. Their application in regular surveillance will clarify the duration and protective nature of humoral responses to SARS-CoV-2.
Publisher
Cold Spring Harbor Laboratory