Author:
Zhao Ting-Ting,Feng Yi-Jing,Doanh Pham Ngoc,Sayasone Somphou,Khieu Virak,Nithikathkul Choosak,Qian Men-Bao,Hao Yuan-Tao,Lai Ying-Si
Abstract
AbstractOpisthorchiasis is an overlooked danger to Southeast Asia. High-resolution disease risk maps are critical but haven’t been available for Southeast Asia. Georeferenced disease data and potential influencing factor data were collected through a systematic review of literatures and open-access databases, respectively. Bayesian spatial-temporal joint models were developed to analyze both point- and area-level disease data, within a logit regression in combination of potential influencing factors and spatial-temporal random effects. The model-based risk mapping identified areas of low, moderate and high prevalence across the study region. Even though the overall population-adjusted estimated prevalence presented a trend down, a total of 12.39 million (95% BCI: 10.10-15.06) people were estimated infected with O. viverrini in 2018 in four major endemic countries (i.e., Thailand, Laos, Cambodia, and Vietnam), highlighting the public health importance of the disease in the study region. The high-resolution risk maps provide valuable information for spatial targeting of opisthorchiasis control interventions.
Publisher
Cold Spring Harbor Laboratory