Comparison of decidual vasculopathy in central and peripheral regions of placenta with implication of lateral growth and spiral artery remodeling

Abstract

AbstractBackgroundDecidual vasculopathy at late gestation was shown to be associated with spiral artery remodeling at implantation. How placental lateral growth is related to spiral artery remodeling in spatiotemporal fashion is to be investigated.DesignThe central and peripheral portions of 105 placentas with decidual vasculopathy at term were examined with or without preeclampsia to see if temporal vascular regeneration was present. Central and peripheral vasculopathy and central and peripheral regeneration were compared.ResultPeripheral portion showed more decidual vasculopathy (88 of total 105, 83.8%) than central portion (72 of total 105, 68.6%, p=0.0018). However, central portion showed more vascular regeneration (51 of total 105, 48.6%) than peripheral portion (23 of total 105, 21.9%, p=0.0024). There is no difference in vasculopathy or regeneration with or without preeclampsia.ConclusionSpiral artery remodeling is non-synchronous during lateral growth and vascular regeneration. This spatiotemporal sequence may help interpretation of morphologic changes of decidual vasculopathy.