Author:
Oja Anna E.,Saris Anno,Ghandour Cherien A.,Kragten Natasja A.M.,Hogema Boris M.,Nossent Esther J.,Heunks Leo M.A.,Cuvalay Susan,Slot Ed,Swaneveld Francis H.,Vrielink Hans,Rispens Theo,van der Schoot Ellen,van Lier René A.W.,Brinke Anja Ten,Hombrink Pleun
Abstract
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding both the immunological processes providing specific immunity and potential immunopathology underlying the pathogenesis of this disease may provide valuable insights for potential therapeutic interventions. Here, we quantified SARS-CoV-2 specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. The observed disparate T and B cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.
Publisher
Cold Spring Harbor Laboratory
Reference51 articles.
1. COVID-19 in real time;Lancet Infect. Dis,2020
2. Clinical Characterisitics of Coronavirus Disease 2019 in China;N. Engl. J. Med,2020
3. The trinity of COVID-19: immunity, inflammation and intervention;Nat. Rev. Immunol,2020
4. Yang, X. et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. 8, 475–481.
5. Pathological findings of COVID-19 associated with acute respiratory distress syndrome;Lancet Respir,2020
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献