Orthogonal Functions for Evaluating Social Distancing Impact on CoVID-19 Spread

Author:

Eng GenghmunORCID

Abstract

AbstractEarly CoVID-19 growth often obeys: , with Ko = [(ln 2)/(tdbl)], where tdbl is the pandemic doubling time, prior to society-wide Social Distancing. Previously, we modeled Social Distancing with tdbl as a linear function of time, where N [t] 1 ≈ exp[+KAt/ (1+,γot)] is used here. Additional parameters besides {Ko, γo} are needed to better model different ρ[t] = dN [t]/dt shapes. Thus, a new Orthogonal Function Model [OFM] is developed here using these orthogonal function series: where N (Z) and Z[t] form an implicit N [t] N (Z[t]) function, giving: with Lm(Z) being the Laguerre Polynomials. At large MF values, nearly arbitrary functions for N [t] and ρ [t] = dN [t]/dt can be accommodated. How to determine {KA, γo} and the {gm; m = (0, +MF)} constants from any given N (Z) dataset is derived, with ρ [t] set by: The bing com USA CoVID-19 data was analyzed using MF = (0, 1, 2) in the OFM. All results agreed to within about 10 percent, showing model robustness. Averaging over all these predictions gives the following overall estimates for the number of USA CoVID-19 cases at the pandemic end: which compares the pre- and post-early May bing com revisions. The CoVID-19 pandemic in Italy was examined next. The MF = 2 limit was inadequate to model the Italy ρ [t] pandemic tail. Thus, regions with a quick CoVID-19 pandemic shutoff may have additional Social Distancing factors operating, beyond what can be easily modeled by just progressively lengthening pandemic doubling times (with 13 Figures).

Publisher

Cold Spring Harbor Laboratory

Reference15 articles.

1. https://www.MedRxiv.org/ID=MedRxiv/2020/043752v1, 03.25.2020, “Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator-days and deaths by US state in the next 4 months”,

2. IHME COVID-19 Health Service Utilization Forecasting Team.

3. https://www.MedRxiv.org/content/10.1101/2020.05.04.20091207v1, https://doi.org/10.1101/2020.05.04.20091207, “Initial Model for the Impact of Social Distancing on CoVID-19 Spread “, Genghmun Eng

4. https://www.geekwire.com/2020/univ-washington--epidemiologists-predict-80000-covid-19-deaths-u-s-july,

5. “Univ. of Washington researchers predict 80,000 COVID-19 deaths in U.S. by July”, Alan Boyle, GeekWire, March 26, 2020.

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