SARS-CoV-2 B.1.1.529 variant (Omicron) evades neutralization by sera from vaccinated and convalescent individuals

Author:

Rössler Annika,Riepler Lydia,Bante David,Laer Dorothee von,Kimpel Janine

Abstract

AbstractRecently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.529 (Omicron) has been described.Here, we analyze titers of neutralizing antibodies of sera from convalescent or vaccinated individuals against the new B.1.1.529 variant and compared them with titers against other Variants of Concern (B.1.1.7, B.1.351, B.1617.2) using replication competent SARS-CoV-2 variants.We found that sera from vaccinated individuals neutralized the B.1.1.529 variant to a much lesser extent than any other variant analyzed. Neutralization capacity against B.1.1.529 was maintained best against sera from super immune individuals (infected and vaccinated or vaccinated and infected).

Publisher

Cold Spring Harbor Laboratory

Reference4 articles.

1. World Health Organization. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern. 26.11.2021; Available from: https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.

2. Network for Genomic Surveillance in South Africa (NGS-SA). SARS-CoV-2 Sequencing Update 26 November 2021. Available from: https://www.nicd.ac.za/wp-content/uploads/2021/11/Update-of-SA-sequencing-data-from-GISAID-26-Nov_Final.pdf

3. Pulliamn JRC , van Schalkwyk C , Govender N et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa. Dec 2, 2021. (https://doi.org/10.1101/2021.11.11.21266068) preprint.

4. Comparison of 4 SARS-CoV-2 neutralization assays;Vaccines (Basel),2020

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