Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus

Author:

Querne Lana Bazan Peters,Bastos Fernanda ZettelORCID,Beirão Breno Castello Branco

Abstract

AbstractHumans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in cattle-raising regions. This article shows an in silico investigation of shared viral epitopes between BCoV and SARS-CoV-2. HLA recognition and lymphocyte reactivity were assessed using freely-available resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for B and T lymphocytes. These data demonstrate that possible cross-protection is being induced by human exposure to cattle.

Publisher

Cold Spring Harbor Laboratory

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