Effectiveness of COVID-19 vaccines against the Omicron (B.1.1.529) variant of concern
Author:
Andrews Nick, Stowe Julia, Kirsebom Freja, Toffa Samuel, Rickeard Tim, Gallagher Eileen, Gower Charlotte, Kall Meaghan, Groves Natalie, O’Connell Anne-Marie, Simons David, Blomquist Paula B., Zaidi Asad, Nash Sophie, Aziz Nurin Iwani Binti Abdul, Thelwall Simon, Dabrera GavinORCID, Myers Richard, Amirthalingam Gayatri, Gharbia Saheer, Barrett Jeffrey C., Elson RichardORCID, Ladhani Shamez N, Ferguson Neil, Zambon Maria, Campbell Colin NJ, Brown Kevin, Hopkins Susan, Chand Meera, Ramsay Mary, Bernal Jamie Lopez
Abstract
AbstractBackgroundA rapid increase in cases due to the SARS-CoV-2 Omicron (B.1.1.529) variant in highly vaccinated populations has raised concerns about the effectiveness of current vaccines.MethodsWe used a test-negative case-control design to estimate vaccine effectiveness (VE) against symptomatic disease caused by the Omicron and Delta variants in England. VE was calculated after primary immunisation with two BNT162b2 or ChAdOx1 doses, and at 2+ weeks following a BNT162b2 booster.ResultsBetween 27 November and 06 December 2021, 581 and 56,439 eligible Omicron and Delta cases respectively were identified. There were 130,867 eligible test-negative controls. There was no effect against Omicron from 15 weeks after two ChAdOx1 doses, while VE after two BNT162b2 doses was 88.0% (95%CI: 65.9 to 95.8%) 2-9 weeks after dose 2, dropping to between 34 and 37% from 15 weeks post dose 2.From two weeks after a BNT162b2 booster, VE increased to 71.4% (95%CI: 41.8 to 86.0%) for ChAdOx1 primary course recipients and 75.5% (95%CI: 56.1 to 86.3%) for BNT162b2 primary course recipients.For cases with Delta, VE was 41.8% (95%CI: 39.4-44.1%) at 25+ weeks after two ChAdOx1 doses, increasing to 93.8% (95%CI: 93.2-94.3%) after a BNT162b2 booster. With a BNT162b2 primary course, VE was 63.5% (95%CI: 61.4 to 65.5%) 25+ weeks after dose 2, increasing to 92.6% (95%CI: 92.0-93.1%) two weeks after the booster.ConclusionsPrimary immunisation with two BNT162b2 or ChAdOx1 doses provided no or limited protection against symptomatic disease with the Omicron variant. Boosting with BNT162b2 following either primary course significantly increased protection.
Publisher
Cold Spring Harbor Laboratory
Reference32 articles.
1. World Health Organization. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern who.int: World Health Organization; 2021 [updated 26 November 2021. Available from: https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern. 2. European Centre for Disease Prevention and Control. Implications of the further emergence and spread of the SARS-CoV-2 B.1.1.529 variant of concern (Omicron) for the EU/EEA – first update 2021 [Available from: https://www.ecdc.europa.eu/sites/default/files/documents/threat-assessment-covid-19-emergence-sars-cov-2-variant-omicron-december-2021.pdf. 3. Cele S , Jackson L , Khan K , Khoury D , Moyo-Gwete T , Tegally H , et al. SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection. medRxiv. 2021:2021.12.08.21267417. 4. Wilhelm A , Widera M , Grikscheit K , Toptan T , Schenk B , Pallas C , et al. Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies. medRxiv. 2021:2021.12.07.21267432. 5. Khoury DS , Cromer D , Reynaldi A , Schlub TE , Wheatley AK , Juno JA , et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nature medicine. 2021.
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