SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron
Author:
Tarke Alison, Coelho Camila H., Zhang Zeli, Dan Jennifer M., Yu Esther Dawen, Methot Nils, Bloom Nathaniel I., Goodwin Benjamin, Phillips Elizabeth, Mallal Simon, Sidney John, Filaci Gilberto, Weiskopf Daniela, da Silva Antunes RicardoORCID, Crotty ShaneORCID, Grifoni Alba, Sette Alessandro
Abstract
SUMMARYWe address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, NVX-CoV2373) cross-recognize SARS-CoV-2 variants. Preservation of at least 83% and 85% for CD4+and CD8+T cell responses was found, respectively, regardless of vaccine platform or variants analyzed. By contrast, highly significant decreases were observed for memory B cell and neutralizing antibody recognition of variants. Bioinformatic analyses showed full conservation of 91% and 94% of class II and class I spike epitopes. For Omicron, 72% of class II and 86% of class I epitopes were fully conserved, and 84% and 85% of CD4+and CD8+T cell responses were preserved. In-depth epitope repertoire analysis showed a median of 11 and 10 spike epitopes recognized by CD4+and CD8+T cells from vaccinees. Functional preservation of the majority of the T cell responses may play an important role as a second-level defense against diverse variants.
Publisher
Cold Spring Harbor Laboratory
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