Author:
Baráth Benjámin R.,Nagy Laszlo
Abstract
Metabolic reprogramming of stem cells is a targetable pathway to control regeneration. Activation of stem cells results in down-regulation of oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) and turns on glycolysis to provide fuel for proliferation and specific signaling events. How cell type-specific events are regulated is unknown. In this issue ofGenes & DevelopmentCiuffoli and colleagues (pp. 151–167) use metabolomic, gene inactivation, and functional approaches to show that phosphoserine aminotransferase (Psat1), an enzyme in serine biosynthesis, is activated in muscle stem cells and contributes to cell expansion and skeletal muscle regeneration via the production of α-ketoglutarate and glutamine.
Funder
ÚNKP-23-2 New National Excellence Program of the Ministry For Culture and Innovation
National Research, Development, and Innovation Fund
National Institutes of Health
Publisher
Cold Spring Harbor Laboratory