How has the municipal availability of theGeneXpert®MTB/RIFsystem affected the detection of drug-resistant tuberculosis in Brazil?

Abstract

ABSTRACTObjectiveTo evaluate the association between the availability ofGeneXpert®MTB/RIFin municipalities and the proportion of people who have access to this diagnostic technology for tuberculosis (TB), as well as the resistance detected by the surveillance system in Brazil.MethodsWe analyzed 4,998 Brazilian municipalities that reported 432,937 new TB cases between 2015 and 2020. We compared municipalities with and without the availability ofGeneXpert®MTB/RIFregarding the prevalence of effective access toGeneXpert®MTB/RIFdiagnosis and that of detected resistance.ResultsMunicipalities with at least oneGeneXpert®MTB/RIFsystem had three times (95%CI 2.9-3.0) the access to diagnostic tests and 80.4% (95%CI 70.6%-90.2%) higher detection of resistance, compared to municipalities without this technology. We estimate that there have been 2,110 cases of undetected resistance during this period in the country.ConclusionsThe availability ofGeneXpert®MTB/RIFsystem in the municipality increased the sensitivity of the surveillance for detecting TB resistance.Public Health implicationsIt is a priority to strengthen laboratory networks and narrow the gap in access to rapid diagnosis in remote areas to improve the detection and control of drug-resistant tuberculosis.