Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages

Abstract

AbstractAttempts to convert a tumor supportive M2-polarized macrophage microenvironment into a tumor suppressive M1-polarized one have recently received considerable attention. However, the specificity of novel compounds, their mode-of-action, and efficacy on presumed target cellsin vivoneeds to be interpreted with caution.