Pathology of natural infection with highly pathogenic avian influenza virus (H5N1) clade 2.3.4.4b in wild terrestrial mammals in the United States in 2022-Reference-Cited by-同舟云学术

Pathology of natural infection with highly pathogenic avian influenza virus (H5N1) clade 2.3.4.4b in wild terrestrial mammals in the United States in 2022

Published:2023-03-12 Issue: Volume: Page:
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Elsmo EJ^ORCID,Wünschmann A,Beckmen KB^ORCID,Broughton-Neiswanger LB^ORCID,Buckles EL,Ellis J,Fitzgerald SD,Gerlach R^ORCID,Hawkins S^ORCID,Ip HS^ORCID,Lankton JS^ORCID,Lemley EM,Lenoch JB^ORCID,Killian ML,Lantz K^ORCID,Long L,Maes R,Mainenti M^ORCID,Melotti J,Moriarty ME,Nakagun S^ORCID,Ruden RM^ORCID,Shearn-Bochsler V^ORCID,Thompson D,Torchetti MK^ORCID,Van Wettere AJ^ORCID,Wise AG,Lim AL^ORCID

Abstract

AbstractThis article describes the first detections of disease due to natural infection with highly pathogenic avian influenza virus (HPAIv) H5N1 of the Eurasian lineage goose/Guangdong clade 2.3.4.4b in wild terrestrial mammals throughout the United States during 2021-2022. Affected mammalian species include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals primarily exhibited neurological signs. Necrotizing meningoencephalitis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.

Publisher

Cold Spring Harbor Laboratory

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