Abstract
AbstractHow did the complex structure of telencephalon evolve? Existing explanations are based on phenomena and lack the first principle. The Darwinian dynamics and the endogenous network theory established a few years ago provide a mathematical and theoretical framework of a dynamical structure, and a general constitutive structure for theory-experiment coupling, respectively, for answering this question from the first principle perspective. By revisiting a gene network that explains the anterior-posterior patterning of the vertebrate telencephalon, we found that with the increase of the cooperative effect in this network, the fixed points gradually evolve, accompanied by the occurrence of two bifurcations. The dynamic behavior of this network consists with the knowledge obtained from experiments on telencephalon evolution. Furtherly, our work drew an answer quantitatively of how the telencephalon anterior-posterior patterning evolved from the pre-vertebrate chordate to the vertebrate and gave a series of verifiable predictions in a first principle manner.Figure Abstract
Publisher
Cold Spring Harbor Laboratory
Reference31 articles.
1. Towards Predictive Stochastic Dynamical Modeling of Cancer Genesis and Progression;Interdisciplinary Sciences: Computational Life Sciences,2010
2. Laws in Darwinian Evolutionary Theory;Physics of Life Reviews,2005
3. Towards Predictive Neural Network Dynamical Theory;Physics of Life Reviews,2021
4. Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution
5. The Dorsoanterior Brain of Adult Amphioxus Shares Similarities in Expression Profile and Neuronal Composition with the Vertebrate Telencephalon;BMC Biology,2021