Abstract
SummaryBehavior requires neural activity across the brain, but most experiments probe neurons in a single area at a time. Here we used multiple Neuropixels probes to record neural activity simultaneously in brain-wide circuits, in mice performing a memory-guided directional licking task. We targeted brain areas that form multi-regional loops with anterior lateral motor cortex (ALM), a key circuit node mediating the behavior. Neurons encoding sensory stimuli, choice, and actions were distributed across the brain. However, in addition to ALM, coding of choice was concentrated in subcortical areas receiving input from ALM, in an ALM-dependent manner. Choice signals were first detected in ALM and the midbrain, followed by the thalamus, and other brain areas. At the time of movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions. Our experiments provide the foundation for neural circuit models of decision-making and movement initiation.
Publisher
Cold Spring Harbor Laboratory
Reference96 articles.
1. “Thirst Regulates Motivated Behavior through Modulation of Brainwide Neural Population Dynamics.” Science (New York;N.Y,2019
2. Batty, Eleanor , Matthew Whiteway , Shreya Saxena , Dan Biderman , Taiga Abe , Simon Musall , Winthrop Gillis , et al. 2019. “BehaveNet: Nonlinear Embedding and Bayesian Neural Decoding of Behavioral Videos.” In Advances in Neural Information Processing Systems. Vol. 32. Curran Associates, Inc. https://proceedings.neurips.cc/paper/2019/hash/a10463df69e52e78372b724471434ec9-Abstract.html.
3. Experimental Studies on the Movements of the Mammalian Tongue;Anatomical Record,1941
4. A relationship between behavioral choice and the visual responses of neurons in macaque MT
5. The Urge to Decide and Act: Implications for Brain Function and Dysfunction;The Neuroscientist,2019
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献