An oral cholera vaccine in the prevention and/or treatment of inflammatory bowel disease

Author:

Meunier MarineORCID,Spillmann Adrian,Rousseaux Christel,Schwamborn Klaus,Hanson Melissa

Abstract

AbstractThe oral cholera vaccine WC-rBS consists of 4 different inactivated strains ofVibrio cholerae(LPS source) admixed with recombinant cholera toxin B subunit. Because of its unique composition and anti-inflammatory properties reported for both CTB and low doses of LPS from other Gram-negative bacteria, we speculated that WC-rBS might have anti-inflammatory potential in a chronic autoimmune disease such as inflammatory bowel diseases. Firstin vitroendotoxin tolerance experiments showed the surprising WC-rBS potential in the modulation of inflammatory responses on both PBMCs and THP1 cells. WC-rBS was further evaluated in the Dextran Sodium Sulfate colitis mouse model. Administrated orally at different dosages, WC-rBS vaccine was safe and showed immunomodulatory properties when administered in a preventive mode (before and during the induction of DSS colitis) as well as in a curative mode (after colitis induction); with improvement of disease activity index (from 27 to 73%) and histological score (from 65 to 88%). Interestingly, the highest therapeutic effect of WC-rBS vaccine was observed with the lowest dosage, showing even better anti-inflammatory properties than mesalamine; an approved 5-aminosalicylic acid drug for treating IBD patients. In summary, this is the first time that a prophylactic medicine, safe and approved for prevention of an infectious disease, showed a benefit in an inflammatory bowel disease model, potentially offering a novel therapeutic modality for IBD patients.

Publisher

Cold Spring Harbor Laboratory

Reference29 articles.

1. Multiple associations between a broad spectrum of autoimmune diseases, chronic inflammatory diseases and cancer;Anticancer Res,2012

2. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

3. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease;J Med Life,2019

4. Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease;N Engl J Med,2021

5. Cholera toxin: a paradigm of a multifunctional protein;Indian J Med Res,2011

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