Blood lipid density decreases at the early-stage of stomach adenocarcinoma

Abstract

ABSTRACTBackgroundInduction of cancer creates many molecular to physiological changes in the human body. Observation of these variations between normal & diseased conditions become the basis of disease diagnosis. Present study analyzed blood lipid profile, relative to changes in genotype, at the early stage of stomach adenocarcinoma.Materials and MethodPresent study was based on establishment of relationship between genotype to phenotype. Genotypic features were collected through RNAseq analysis, which was further mapped with phenotypic expression in the form of blood lipid profile.ResultsTo observe the significance difference between phenotypic expressions of normal and cancerous condition, gene signatures from multiple sources of studies were mapped with blood lipid profile including: Total Cholesterol, LDL Cholesterol, HDL Cholesterol, Triglycerides, Non-HDL-C, and TG to HDL ratio. Significance difference found between phenotypic expression of normal and cancerous condition.ConclusionThrough multi-signature-based population observation, it was found that blood-lipid density decreases at the early-stage of stomach adenocarcinoma. Further, blood-lipid profile can be used for early disease prediction of stomach adenocarcinoma as well as other cancer types.