Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022

Author:

Hall Victoria JORCID,Insalata Ferdinando,Foulkes SarahORCID,Kirwan PeterORCID,Sparkes Dominic,Atti AnaORCID,Cole MichelleORCID,Lacy Elen de,Price Lesley,Corrigan Diane,Brown Colin S,Islam Jasmin,Charlett AndreORCID,Hopkins SusanORCID,

Abstract

ABSTRACTThird doses of COVID-19 vaccines were widely deployed following primary vaccine course waning and emergence of the Omicron-variant. We investigated protection from third-dose vaccines and previous infection against SARS-CoV-2 infection during Delta-variant and Omicron-variant (BA.1 & BA.2) waves in our frequently PCR-tested cohort of healthcare-workers.

Publisher

Cold Spring Harbor Laboratory

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