Author:
Drake Katherine A.,Talantov Dimitri,Tong Gary J.,Lin Jack T.,Verheijden Simon,Katz Samuel,Leung Jacqueline M.,Yuen Benjamin,Krishna Vinod,Wu Michelle J.,Sutherland Alex,Short Sarah A.,Kheradpour Pouya,Mumbach Maxwell,Franz Kate,Trifonov Vladimir,Lucas Molly V.,Merson James,Kim Charles C.,
Abstract
AbstractThe pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a rapid response by the scientific community to further understand and combat its associated pathologic etiology. A focal point has been on the immune responses mounted during the acute and post-acute phases of infection, but the immediate post-diagnosis phase remains relatively understudied. We sought to better understand the immediate post-diagnosis phase by collecting blood from study participants soon after a positive test and identifying molecular associations with longitudinal disease outcomes. Multi-omic analyses identified differences in immune cell composition, cytokine levels, and cell subset-specific transcriptomic and epigenomic signatures between individuals on a more serious disease trajectory (Progressors) as compared to those on a milder course (Non-progressors). Higher levels of multiple cytokines were observed in Progressors, with IL-6 showing the largest difference. Blood monocyte cell subsets were also skewed, showing a comparative decrease in non-classical CD14−CD16+and intermediate CD14+CD16+monocytes. Additionally, in the lymphocyte compartment, CD8+T effector memory cells displayed a gene expression signature consistent with stronger T cell activation in Progressors. Importantly, the identification of these cellular and molecular immune changes occurred at the early stages of COVID-19 disease. These observations could serve as the basis for the development of prognostic biomarkers of disease risk and interventional strategies to improve the management of severe COVID-19.One Sentence SummaryImmunological changes associated with COVID-19 progression can be detected during the early stages of infection.
Publisher
Cold Spring Harbor Laboratory
Reference89 articles.
1. Clinical and immunological features of severe and moderate coronavirus disease 2019
2. Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia;J. Infect. Dis,2020
3. Clinical update on COVID-19 for the emergency and critical care clinician: Medical management;Am. J. Emerg. Med,2022
4. The WHO estimates of excess mortality associated with the COVID-19 pandemic;Nature,2022
5. E. Mathieu , H. Ritchie , L. Rodés-Guirao , C. Appel , C. Giattino , J. Hasell , B. Macdonald , S. Dattani , D. Beltekian , E. Ortiz-Ospina , M. Roser , Coronavirus Pandemic (COVID-19). Our World in Data (2020) (available at https://ourworldindata.org/coronavirus).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献