Reduced frequency of clonal hematopoiesis in Parkinson’s disease

Abstract

AbstractTo test if clonal hematopoiesis of indeterminate potential (CHIP) is associated with the incidence of Parkinson’s Disease (PD), we analyzed blood whole exome sequencing data from 181 healthy controls and 391 PD subjects in the Parkinson’s Progression Markers Initiative. We observed an age-related increase of CHIP carriers in the healthy controls. Surprisingly, the percentage of CHIP carriers was significantly lower in PD patients than in age-matched controls.