Ectopically expressedAirnlncRNA deposits Polycomb with a potency that rivalsXist

Abstract

AbstractWe report that when expressed at similar levels from an isogenic locus, theAirnlncRNA induces Polycomb deposition with a potency that rivalsXist. However, when subject to the same degree of promoter activation,Xistis more abundant and more potent thanAirn. Our data definitively demonstrate that theAirnlncRNA is functional and suggest thatXistachieved extreme potency in part by evolving mechanisms to promote its own abundance.