Modulation of dorsal premotor cortex disrupts neuroplasticity of primary motor cortex in young and older adults

Abstract

AbstractAlthough transcranial magnetic stimulation (TMS) research demonstrates that dorsal premotor cortex (PMd) influences neuroplasticity within primary motor cortex (M1), it is unclear how ageing modifies this communication. The present study investigated the influence of PMd on different indirect (I) wave inputs within M1 that mediate cortical plasticity in young and older adults. 15 young and 15 older participants completed two experimental sessions that examined the effects of intermittent theta burst stimulation (iTBS) to M1 when preceded by iTBS (PMd iTBS-M1 iTBS) or sham stimulation (PMd sham-M1 iTBS) to PMd. Changes in corticospinal excitability post-intervention were assessed with motor evoked potentials (MEP) recorded from right first dorsal interosseous using posterior-anterior (PA) and anterior-posterior (AP) current single-pulse TMS (PA1mV; AP1mV; PA0.5mV, early I-wave; AP0.5mV, late I-wave). Although PA1mVdid not change post-intervention (P= 0.628), PMd iTBS-M1 iTBS disrupted the expected facilitation of AP1mV(to M1 iTBS) in young and older adults (P= 0.002). Similarly, PMd iTBS-M1 iTBS disrupted PA0.5mVfacilitation in young and older adults (P= 0.030), whereas AP0.5mVfacilitation was not affected in either group (P= 0.218). This suggests that while PMd specifically influences the plasticity of early I-wave circuits, this communication is preserved in older adults.