Abstract
AbstractIn mammals, genomic imprinting results from different sets of epigenetic marks that distinguish the parental origins of loci in the progeny. Epigenetic reprogramming of genomic imprinting is necessary to establish a totipotent cell state. The consecutive erasure of parental epigenetic marks and the deposition of new marks occurs alongside major life stage transitions including gametogenesis and fertilization. However, despite occurring concomitantly with gametogenesis, the role of meiosis in epigenetic reprogramming has received little attention. To address this question, we use the model bryophyteMarchantia polymorpha. Following the haploid reproductive phase of this land plant, the expression of the paternal genome is silenced by the histone modification H3K27me3 in the short-lived diploid embryo. We show that imprinting is erased during meiosis, which occurs separately from gametogenesis and fertilization in Marchantia. The epigenetic reprogramming initiated during meiosis is completed in the meiotic spores where the chromatin landscape of the next haploid generation is establishedde novo. Hence, our findings illustrate a potential role for meiosis in epigenetic reprogramming that may be generalized to other sexually reproducing species.
Publisher
Cold Spring Harbor Laboratory
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献