Evaluation of MRI sequences for quantitative T1 brain mapping

Abstract

AbstractT1 mapping constitutes a quantitative MRI technique finding significant application in brain imaging. It allows improved evaluation of contrast uptake, blood perfusion, volume, and provides more specific biomarkers of disease progression compared to conventional T1-weighted images. While there are many techniques for T1-mapping, there is also a wide range of reported T1-values in tissues, raising the issue of protocols’ reproducibility and standardization. The gold standard for obtaining T1-maps is based on acquiring IR-SE sequence. Widely used alternative sequences are IR-SE-EPI, VFA (DESPOT), DESPOT-HIFI and MP2RAGE that speed up scanning and fitting procedures. A custom MRI phantom was used to assess the reproducibility and accuracy of the different methods. All scans were performed using a 3T Siemens Prisma scanner. The acquired data were processed using two different codes. The main difference was observed for VFA (DESPOT) which grossly overestimated T1 relaxation time by 214 ms [CI: 126 270 ms] compared to the IR-SE sequence. MP2RAGE and DESPOT-HIFI sequences gave slightly shorter T1 than IR-SE (∼20 to 30ms) and can be considered as alternative and time-efficient methods for acquiring accurate T1 maps of the human brain, while IR-SE-EPI gave identical results, at a cost of a lower image quality.