Author:
Wen Zhexing,Song Hongjun,Ming Guo-li
Abstract
The re-emergence of Zika virus (ZIKV), a mosquito-borne and sexually transmitted flavivirus circulating in >70 countries and territories, poses a significant global threat to public health due to its ability to cause severe developmental defects in the human brain, such as microcephaly. Since the World Health Organization declared the ZIKV outbreak a Public Health Emergency of International Concern, remarkable progress has been made to gain insight into cellular targets, pathogenesis, and underlying biological mechanisms of ZIKV infection. Here we review the current knowledge and progress in understanding the impact of ZIKV exposure on the mammalian brain development and discuss potential underlying mechanisms.
Funder
National Institutes of Health
Maryland Stem Cell Research Fund
Foundation for Prader-Willi Research
Emory University
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
128 articles.
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