Abstract
AbstractSenna torais a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we sequenced and annotated the genome ofS. toraat the chromosome level with contig N50 and super-scaffold N50 of 4.03 Mb and 41.7 Mb. Comparison among related plant species showed that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded inS. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identified a CHS-L responsible for biosynthesis of anthraquinones, the first example in plants. TheS. torareference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.One Sentence SummaryThe chromosome-scale reference genome of a medicinal plantSenna tora, transcriptomics, metabolomics, and biochemical analysis provide new insights into anthraquinone biosynthesis in plants.
Publisher
Cold Spring Harbor Laboratory
Reference38 articles.
1. M. o. A. National Medicinal Plants Board, Government of India, Medicinal List. (2020, March 28).
2. Alizarin and chrysazin inhibit biofilm and hyphal formation by Candida albicans;Front Cell Infect Microbiol,2017
3. The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera;Phytotherapy Research,2019
4. anti-herpetic, anti-dengue and antineoplastic activities of simple and heterocycle-fused derivatives of terpenyl-1,4-naphthoquinone and 1,4-anthraquinone;Molecules,2019
5. Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways;PLoS One,2018
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献