Disability-Adjusted Life-Years (DALYs) for Breast Cancer and Risk Factors in 195 countries: Findings from Global Burden of Disease Study 2017

Abstract

AbstractBackgroundBreast cancer is a leading cancer burden for females. In order to picture the patterns and time trends of the breast cancer burden across different regions, the disability-adjusted life years (DALYs) were used to estimate breast cancer burden in 1990–2017.MethodsData from Global Burden of Disease Study 2017 (GBD 2017) was used to estimate the disability-adjusted life-years (DALYs) for the burden of breast cancer by locations, regions, years (with corresponding 95% uncertainty intervals [UI]). Besides, the associated potentially modifiable risk factors were estimated to provide targeted means for controlling the burden of breast cancer.ResultsAll-age numbers of DALYs reached over 17.42 million years in 2017 globally, despite the decreasing trends in all-age and age-standardized rate. The rates for DALYs was the highest in Western Sub-Saharan Africa [694.23 (534.43 to 906.05)] in 2017. High fasting plasma glucose [1.07 million (0.20 to 2.43) DALYs] and high body-mass index (BMI) [0.81 million (0.27 to 1.53) DALYs] have become great attributors to DALYs of breast cancer in 2017.ConclusionsThe levels and trends in causes of DALYs of breast cancer, generally show similiarities between 2007 and 2017, although differences exist. The differences observed countries can be attributed high fasting plasma glucose and high body-mass index across the world. Concerned efforts at national and regional levels are required to tackle the emerging burden of breast cancer in the world.