Abstract
AbstractTranscranial Doppler (TCD) blood flow velocity has been extensively used in biomedical research as it provides a cost-effective and relatively simple approach to assess changes in cerebral blood flow dynamics and track cerebrovascular health status. In this paper, we introduce a new TCD based timing index, TItcd, as an indicator of vascular stiffening and vascular health. We investigate the correlations of the new index and the existing indices, namely the pulsatility index (PItcd) and the augmentation index (AITCD), with age, cardiorespiratory fitness (CRF) and magnetic resonance imaging (MRI) blood flow pulsatility index (PImri). Notably, the new TItcd index showed stronger correlations with CRF (r = −0.79) and PImri (r = 0.53) compared to AItcd (r = −0.65 with CRF and no significant correlation with PImri) and PITCD (no significant correlations with CRF or PImri) and similar correlations with age as AItcd. The clearer relationship of the proposed timing index with vascular aging factors represented by cerebrovascular resistance (CVR) suggests its utility as an early indicator of vascular stiffening.
Publisher
Cold Spring Harbor Laboratory
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