Intrinsic/extrinsic duality of large-scale neural functional integration in the human brain

Author:

Sjøgård Martin,Bourguignon Mathieu,Costers Lars,Dumitrescu Alexandru,Coolen Tim,Roshchupkina Liliia,Destoky Florian,Bertels Julie,Niesen Maxime,Ghinst Marc Vander,van Schependom Jeroen,Nagels Guy,Urbain Charline,Peigneux Philippe,Goldman Serge,Woolrich Mark W.,De Tiège Xavier,Wens Vincent

Abstract

AbstractHuman brain activity is not merely responsive to environmental context but includes intrinsic dynamics, as suggested by the discovery of functionally meaningful neural networks at rest, i.e., even without explicit engagement of the corresponding function. Yet, the neurophysiological coupling mechanisms distinguishing intrinsic (i.e., task-invariant) from extrinsic (i.e., task-dependent) brain networks remain indeterminate. Here, we investigated functional brain integration using magnetoencephalography throughout rest and various tasks recruiting different functional systems and modulating perceptual/cognitive loads. We demonstrated that two distinct modes of neural communication continually operate in parallel: extrinsic coupling supported by phase synchronization and intrinsic integration encoded in amplitude correlation. Intrinsic integration also contributes to phase synchronization, especially over short (second-long) timescales, through modulatory effects of amplitude correlation. Our study establishes the foundations of a novel conceptual framework for human brain function that fundamentally relies on electrophysiological features of functional integration. This framework blurs the boundary between resting-state and task-related neuroimaging.

Publisher

Cold Spring Harbor Laboratory

Reference108 articles.

1. Marshall, D. & Weatherson, B. Intrinsic vs. Extrinsic Properties. in The Stanford Encyclopedia of Philosophy (ed. Zalta, E. N. ) (Metaphysics Research Lab, Stanford University, 2018).

2. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

3. The Dynamical Balance of the Brain at Rest

4. Correspondence of the brain's functional architecture during activation and rest

5. Two views of brain function

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3