Author:
Brinks Ralph,Hoyer Annika
Abstract
AbstractWe compare two approaches for simulating events in the illness-death model in a test example about type 2 diabetes in Germany. The first approach is a discrete event simulation, where relevant events, i.e., onset of disease and death, are simulated for each subject individually. The second approach is the Doob-Gillespie algorithm, which simulates the number of people in each state of the illness-death model at each point in time. The algorithms are compared in terms of bias, variance and speed. Based on the results of the comparison in the test example, we assess coverage of the corresponding Wald confidence intervals.
Publisher
Cold Spring Harbor Laboratory
Reference20 articles.
1. The rising pandemic of mental disorders and associated chronic diseases and disabilities
2. Chronic Diseases: The Emerging Pandemic;Clinical and Translational Science,2011
3. Coronary heart disease: pandemic in a true sense;Journal of Cardiovascular and Thoracic Research,2013
4. Global Health Estimates 2016, Estimated deaths by age, sex and cause https://www.who.int/healthinfo/global_burden_disease/GHE2016_Deaths_Global_2000_2016.xls, last access: Mar 30, 2020
5. United Nations General Assembly, Resultion 73/2, October 10th 2018