Cell-density independent increased lymphocyte production and loss rates post-autologous hematopoietic stem cell transplantation

Author:

Baliu-Piqué MarionaORCID,van Hoeven Vera,Drylewicz Julia,van der Wagen Lotte E.,Janssen Anke,Otto Sigrid A.,van Zelm Menno C.,de Boer Rob J.,Kuball Jürgen,Borghans José A.M.,Tesselaar Kiki

Abstract

AbstractLymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and survival rates increase homeostatically when lymphocyte numbers decrease. This widely-accepted concept is largely based on experiments in mice. In humans, lymphocyte reconstitution usually occurs very slowly, which challenges the idea that density dependent homeostasis aids recovery from lymphopenia. Using in vivo deuterium labelling, we quantified lymphocyte production and survival rates in patients who underwent an autologous hematopoietic stem cell transplantation (autoHSCT). We indeed found that the production rates of most T-cell and B-cell subsets in autoHSCT-patients were 2 to 8-times higher than in healthy controls. These increased lymphocyte production rates went hand in hand with a 3 to 9-fold increase in cell loss rates, and both rates did not normalize when cell numbers did. This challenges the concept of homeostatic regulation of lymphocyte production and survival rates in humans.

Publisher

Cold Spring Harbor Laboratory

Reference43 articles.

1. Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors;Immun. Ageing,2016

2. Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

3. Population Biology of Lymphocytes: The Flight for Survival

4. T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses;J. Immunol,1984

5. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells;J. Immunol,1987

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3