Author:
Hosier Hillary,Farhadian Shelli,Morotti Raffaella A.,Deshmukh Uma,Lu-Culligan Alice,Campbell Katherine H.,Yasumoto Yuki,Vogels Chantal B.F.,Casanovas-Massana Arnau,Vijayakumar Pavithra,Geng Bertie,Odio Camila D.,Fournier John,Brito Anderson F.,Fauver Joseph R.,Liu Feimei,Alpert Tara,Tal Reshef,Szigeti-Buck Klara,Perincheri Sudhir,Larsen Christopher,Gariepy Aileen M.,Aguilar Gabriela,Fardelmann Kristen L.,Harigopal Malini,Taylor Hugh S.,Pettker Christian M.,Wyllie Anne L.,Cruz Charles Dela,Ring Aaron M.,Grubaugh Nathan D.,Ko Albert I.,Horvath Tamas L.,Iwasaki Akiko,Reddy Uma M.,Lipkind Heather S.
Abstract
AbstractBackgroundThe effects of Covid-19 in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic Covid-19 complicated by severe preeclampsia and placental abruption.MethodsWe analyzed placenta for the presence of SARS-CoV-2 through molecular and immunohistochemical assays and by and electron microscopy, and we measured the maternal antibody response in blood to this infection.ResultsSARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the maternal-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for vasculopathy typically associated with preeclampsia.ConclusionThis case demonstrates, for the first time, SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with Covid-19.
Publisher
Cold Spring Harbor Laboratory
Cited by
28 articles.
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