Author:
Poor Hooman D.,Ventetuolo Corey E.,Tolbert Thomas,Chun Glen,Serrao Gregory,Zeidman Amanda,Dangayach Neha S.,Olin Jeffrey,Kohli-Seth Roopa,Powell Charles A.
Abstract
AbstractCritically ill COVID-19 patients have relatively well-preserved lung mechanics despite severe gas exchange abnormalities, a feature not consistent with classical ARDS but more consistent with pulmonary vascular disease. Patients with severe COVID-19 also demonstrate markedly abnormal coagulation, with elevated D-dimers and higher rates of venous thromboembolism. We present four cases of patients with severe COVID-19 pneumonia with severe respiratory failure and shock who demonstrated immediate improvements in gas exchange and/or hemodynamics with systemic tPA.Subject category4.6 ICU Management and Outcome
Publisher
Cold Spring Harbor Laboratory
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