Author:
Khan Raja Ishaq Nabi,Sahu Amit Ranjan,Malla Waseem Akram,Praharaj Manas Ranjan,Hosamani Neelima,Kumar Shakti,Gupta Smita,Sharma Shweta,Saxena Archana,Varshney Anshul,Singh Pragya,Verma Vinay,Kumar Puneet,Singh Gyanendra,Pandey Aruna,Saxena Shikha,Gandham Ravi Kumar,Tiwari Ashok Kumar
Abstract
AbstractTranscriptome profiling of Vrindavani and Tharparkar cattle revealed that more numbers of genes dysregulated in Vrindavani than in Tharparkar. A contrast in gene expression was observed with 18.5 % of upregulated genes in Vrindavani were downregulated in Tharparkar and 17.5% upregulated genes in Tharparkar were downregulated in Vrindavani. Functional annotation of genes differentially expressed in Tharparkar and Vrindavani revealed that the systems biology in Tharparkar is moving towards counteracting the effects due to heat stress. Unlike Vrindavani, Tharparkar is not only endowed with higher expression of the scavengers (UBE2G1, UBE2S, andUBE2H) of misfolded proteins but also with protectors (VCP, Serp1, andCALR) of naïve unfolded proteins. Further, higher expression of the antioxidants in Tharparkar enables it to cope up with higher levels of free radicals generated as a result of heat stress. In this study we found relevant genes dysregulated in Tharparkar in the direction that can counter heat stress.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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