Author:
Smith Caroline J.,Kingsbury Marcy A.,Dziabis Julia E.,Hanamsagar Richa,Malacon Karen E.,Tran Jessica N.,Norris Haley A.,Gulino Mary,Bilbo Staci D.
Abstract
AbstractDecreases in social behavior are a hallmark aspect of acute “sickness behavior” in response to infection. However, immune insults that occur during the perinatal period may have long-lasting consequences for adult social behavior by impacting the developmental organization of underlying neural circuits. Microglia, the resident immune cells of the central nervous system, are sensitive to immune stimulation and play a critical role in the developmental sculpting of neural circuits, making them likely mediators of this process. Here, we investigated the impact of a postnatal day (PND) 4 lipopolysaccharide (LPS) challenge on social behavior in adult mice. Somewhat surprisingly, neonatal LPS treatment decreased sociability in adult female, but not male mice. LPS-treated females also displayed reduced social interaction and social memory in a social discrimination task as compared to saline-treated females. Somatostatin (SST) interneurons within the anterior cingulate cortex (ACC) have recently been suggested to modulate a variety of social behaviors. Interestingly, the female-specific changes in social behavior observed here were accompanied by an increase in SST interneuron number in the ACC. Finally, these changes in social behavior and SST cell number do not appear to depend on microglial inflammatory signaling, because microglia-specific genetic knock-down of myeloid differentiation response protein 88 (MyD88; the removal of which prevents LPS from increasing proinflammatory cytokines such as TNFα and IL-1β) did not prevent these LPS-induced changes. This study provides novel evidence for enduring effects of neonatal immune activation on social behavior and SST interneurons in females, independent of microglial inflammatory signaling.
Publisher
Cold Spring Harbor Laboratory
Reference77 articles.
1. The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
2. Differential Effects of Lipopolysaccharide on Pup Retrieving and Nest Building in Lactating Mice
3. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014;Morbidity and Mortality Weekly Report. Surveillance Summaries,2018
4. Sex bias in neuroscience and biomedical research
5. Prefrontal Cortex and Social Cognition in Mouse and Man;Frontiers in Psychology,2015
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