Author:
Weiskopf Daniela,Schmitz Katharina S.,Raadsen Matthijs P.,Grifoni Alba,Okba Nisreen M.A.,Endeman Henrik,van den Akker Johannes P.C.,Molenkamp Richard,Koopmans Marion P.G.,van Gorp Eric C.M.,Haagmans Bart L.,de Swart Rik L.,Sette Alessandro,de Vries Rory D.
Abstract
AbstractCOVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity.
Publisher
Cold Spring Harbor Laboratory
Cited by
47 articles.
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