Author:
Chatterjee Amar Nath,Basir Fahad Al
Abstract
AbstractThe current emergence of coronavirus (SARS-CoV-2) puts the world in threat. The structural research on the receptor recognition by SARS-CoV-2 has identified the key interactions between SARS-CoV-2 spike protein and its host (epithelial cell) receptor, also known as angiotensin-converting enzyme 2 (ACE2). It controls both the crossspecies and human-to-human transmissions of SARS-CoV-2. In view of this, we propose and analyze a mathematical model for investigating the effect of CTL responses over the viral mutation to control the viral infection when a postinfection immunostimulant drug (pidotimod) is administered at regular intervals. Dynamics of the system with and without impulses have been analyzed using the basic reproduction number. This study shows that the proper dosing interval and drug dose both are important to eradicate the viral infection.
Publisher
Cold Spring Harbor Laboratory
Reference33 articles.
1. World Health Organization, (2020). Considerations for quarantine of individuals in the context of containment for coronavirus disease (COVID-19): interim guidance, 29 February 2020.
2. World Health Organization, 2020. WHO Director-General’s opening remarks at the media briefing on COVID-19-11 March 2020. Geneva, Switzerland.
3. Zhou, P. et al. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. Published online February 3, 2020. https://doi.org/10.1038/s41586-020-2012-7.
4. Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus
5. A novel coronavirus from patients with pneumonia in China;N. Engl. J. Med,2019
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