Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract

Author:

Lee Jaewon J.ORCID,Kopetz ScottORCID,Vilar EduardoORCID,Shen John PaulORCID,Chen KenORCID,Maitra AnirbanORCID

Abstract

COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world and was declared a pandemic by the World Health Organization, thus leading to a rapid surge in the efforts to understand the mechanisms of transmission, methods of prevention, and potential therapies. While COVID-19 frequently manifests as a respiratory infection,1 there is evidence for infection of the gastrointestinal (GI) tract1–4 with documented viral RNA shedding in the stool of infected patients.2,4 In this study, we aimed to investigate the expression of ACE2 and TMPRSS2, which are required for SARS-CoV-2 entry into mammalian cells,5 from single-cell RNA sequencing (scRNA-seq) datasets of five different parts of the GI tract: esophagus, stomach, pancreas, small intestine, and colon/rectum.

Publisher

Cold Spring Harbor Laboratory

Reference7 articles.

1. Guan WJ , Ni ZY , Hu Y , et al. N Engl J Med 2020 [E-pub ahead of print].

2. First Case of 2019 Novel Coronavirus in the United States

3. Xiao F , Tang M , Zheng X , et al. Gastroenterology 2020 [E-pub ahead of print].

4. Wolfel R , Corman VM , Guggemos W , et al. Nature 2020 [E-pub ahead of print].

5. Hoffmann M , Kleine-Weber H , et al. Cell 2020 [E-pub ahead of print].

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