Lipid-Modulating Agents for Prevention or Treatment of COVID-19 in Randomized Trials

Author:

Talasaz Azita H.,Sadeghipour Parham,Aghakouchakzadeh Maryam,Dreyfus Isaac,Kakavand Hessam,Ariannejad Hamid,Gupta Aakriti,Madhavan Mahesh V.,Van Tassell Benjamin W.,Jimenez David,Monreal Manuel,Vaduganathan Muthiah,Fanikos John,Dixon Dave L,Piazza Gregory,Parikh Sahil A.,Bhatt Deepak L.,Lip Gregory YHORCID,Stone Gregg W.,Krumholz Harlan M.ORCID,Libby Peter,Goldhaber Samuel Z.,Bikdeli Behnood

Abstract

ABSTRACTCoronavirus disease 2019 (COVID-19) is associated with systemic inflammation, endothelial activation, and multi-organ manifestations. Lipid modulating agents may be useful in treating patients with COVID-19. They may inhibit viral entry by lipid raft disruption or ameliorate the inflammatory response and endothelial activation. In addition, dyslipidemia with lower high-density lipoprotein cholesterol and higher triglycerides portends worse outcome in patients with COVID-19. Upon a systematic search, 40 RCTs with lipid modulating agents were identified, including 17 statin trials, 14 omega-3 fatty acids RCTs, 3 fibrates RCTs, 5 niacin RCTs, and 1 dalcetrapib RCT for management or prevention of COVID-19. This manuscript summarizes the ongoing or completed randomized controlled trials (RCTs) of lipid modulating agents in COVID-19 and the implications of these trials for patient management.

Publisher

Cold Spring Harbor Laboratory

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