Generic solving of one-compartment toxicokinetic models
Author:
Charles SandrineORCID, Ratier AudeORCID, Lopes ChristelleORCID
Abstract
AbstractThis paper gives the full analytical solution of the generic set of ordinary differential equations that define one-compartment toxicokinetic models. These models describe uptake and elimination processes taking place within living organisms when exposed to chemical substances. The models solved in this paper consider living organisms as a unique compartment, into which a parent compound enters via several possible exposure routes and from which it is eliminated as well as its potential metabolites. Benefiting from generic solutions of one-compartment toxicokinetic models is particularly useful when fitting them to experimental data, facilitating the writing of the inference algorithms leading to parameter estimates. Additionally, these models are of crucial interest in environmental risk assessment for the calculation of bioaccumulation metrics as required by regulators in support of decision making when they evaluate dossiers for marketing authorisation of active substances.Abstract FigureGraphical abstract
Publisher
Cold Spring Harbor Laboratory
Reference25 articles.
1. Significance of xenobiotic metabolism for bioaccumulation kinetics of organic chemicals in gammarus pulex;Environmental Science & Technology,2012 2. Baudrot, V. , Ratier, A. , Kaag, M. , Lopes, C. , Siberchicot, A. , & Charles, S. (2021). rbioacc: an R-package to analyse toxicokinetic data. URL https://doi.org/10.5281/zenodo.5092316{\#}.YO7d5xJ1Dn8.mendeley 3. Charles, S. , Ratier, A. , Baudrot, V. , Multari, G. , Siberchicot, A. , Wu, D. , & Lopes, C. (2021). Taking full advantage of modelling to better assess environmental risk due to xenobiotics. Environmental Science and Pollution Research, published on-line. URL https://www.biorxiv.org/content/10.1101/2021.03.24.436474v2 https://doi.org/10.1101/2021.03.24.436474 4. Côté, J. , Bonvalot, Y. , Carrier, G. , Lapointe, C. , Fuhr, U. , Tomalik-Scharte, D. , Wachall, B. , & Bouchard, M. (2014). A novel toxicokinetic modeling of cypermethrin and permethrin and their metabolites in humans for dose reconstruction from biomarker data. PLoS ONE, 9 (2). 5. Crookes, M. J. , & Brooke, D. N. (2011). Estimation of fish bioconcentration factor ( BCF ) from depuration data. Tech. rep., Environment Agency, Horizon House, Bristol, UK.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|