Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

Author:

Caniels Tom G.,Bontjer Ilja,van der Straten Karlijn,Poniman Meliawati,Burger Judith A.,Appelman Brent,Lavell Ayesha H.A.,Oomen Melissa,Godeke Gert-Jan,Valle Coralie,Mögling Ramona,van Willigen Hugo D.G.,Wynberg Elke,Schinkel Michiel,van Vught Lonneke A.,Guerra Denise,Snitselaar Jonne L.,Chaturbhuj Devidas N.,Martin Isabel Cuella,Moore John P.,de Jong Menno D.,Reusken Chantal,Sikkens Jonne J.,Bomers Marije K.,de Bree Godelieve J.,van Gils Marit J.,Eggink Dirk,Sanders Rogier W.,

Abstract

AbstractEmerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.1.7, B.1.351 and P.1) in cohorts of COVID-19 patients ranging in disease severity (n = 69) and recipients of the Pfizer/BioNTech vaccine (n = 50). Spike binding and neutralization against all three VOC was substantially reduced in the majority of samples, with the largest 4-7-fold reduction in neutralization being observed against B.1.351. While hospitalized COVID-19 patients and vaccinees maintained sufficient neutralizing titers against all three VOC, 39% of non-hospitalized patients did not neutralize B.1.351. Moreover, monoclonal neutralizing antibodies (NAbs) show sharp reductions in their binding kinetics and neutralizing potential to B.1.351 and P.1, but not to B.1.1.7. These data have implications for the degree to which pre-existing immunity can protect against subsequent infection with VOC and informs policy makers of susceptibility to globally circulating SARS-CoV-2 VOC.

Publisher

Cold Spring Harbor Laboratory

Reference47 articles.

1. An interactive web-based dashboard to track COVID-19 in real time

2. Weekly epidemiological update on COVID-19-13 April 2021, (available at https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-1913-april-2021).

3. A. Rambaut , N. Loman , O. Pybus , W. Barclay , J. Barrett , A. Carabelli , T. Connor , T. Peacock , D. L. Robertson , E. Volz , Others, Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Genom. Epidemiol (2020).

4. Detection of a SARS-CoV-2 variant of concern in South Africa;Nature,2021

5. N. R. Faria , I. M. Claro , D. Candido , L. A. Moyses Franco , P. S. Andrade , T. M. Coletti , C. A. M. Silva , F. C. Sales , E. R. Manuli , R. S. Aguiar , Others, Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. Virological (2021) (available at https://www.icpcovid.com/sites/default/files/2021-01/Ep%20102-1%20Genomic%20characterisation%20of%20an%20emergent%20SARS-CoV-2%20lineage%20in%20Manaus%20Genomic%20Epidemiology%20-%20Virological.pdf).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3